EDTA is an allergen and causes skin irritations. APEs and APDs are hormone disruptors. Sodium perborate is a skin, eye, and respiratory tract irritant, and also contains borax, a soil pollutant. Chlorine bleaching produces dioxins, a substance that is extremely dangerous to humans and wildlife. Dioxins are found in the atmosphere, soil, water, and in our food supply. Dioxins are linked to skin problems, cancer, reproductive problems, behavioral problems, and diabetes. Dioxins are also persistent in the environment, meaning they do not easily break down. Phosphates are water pollutants and contribute to algal blooms (which kill off fish populations) when they enter water from wastewater treatment plants. Synthetic musk fragrances are persistent, bioaccumulate in fatty tissue, and are poorly degradable in the environment. In addition, they are hormone disruptors and are linked to cancer in laboratory tests. Whiteners are harmful to fish and aquatic life, cause bacteria to mutate, and can cause skin irritations in humans.